Researchers Suggest Adjusting the Glucose Level We Think of as Hypoglycemia

5922

An article published in Diabetologia this month challenges the accepted glucose cut-off values that define hypoglycemia because they have a major effect on reported frequencies of hypoglycemia.

Researchers set out to quantify the relationship between the frequency of hypoglycemia and various glucose cut-off points for the definition of hypoglycemia, within a range of A1c strata.

Data from two trials examining insulin glargine dose titration in 12,837 type 2 participants with diabetes starting insulin therapy were combined. Curves for hypoglycemia frequency plotted against endpoint A1c level were constructed, using a range of glucose cut-off points for hypoglycemia.

During the 12-week study period, 3,912 patients recorded 21,592 hypoglycemic episodes, which were classified as either “severe,” “symptomatic,” or “asymptomatic” events. 

The researchers concluded that the glucose cut-off point defining hypoglycemia greatly affects the reported frequency of hypoglycemia. In order to have clinical relevance, and if hypoglycemia is to be defined by a predetermined glucose level, then the cut-off should be set at a lower level than the threshold of 3.9 mmol/l proposed by the American Diabetes Association.

Read the journal article here.

Click here to view/write comments
Diabetes Health Medical Disclaimer
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.