For type 1s who fast during Ramadan, it was discovered that blood-sugar control—measured by after-meal readings—was improved and hypoglycemia significantly reduced when using insulin lispro compared with Regular human insulin.
In a study presented in Diabetes Metabolism (2001 Sep;27(4):482-486), researchers in Morocco randomized 64 people with diabetes for a two-week study. Insulin lispro or Regular insulin was given together with NPH insulin, twice daily before the morning and evening meals for two weeks. Blood glucose was self-monitored at fasting morning and evening, and one and two hours after the post-sunset meal on three consecutive days at the end of each treatment period.
The researchers found that the two-hour blood-glucose excursion after the post-sunset meal was lower with insulin lispro than with Regular human insulin. Daily insulin doses did not differ between treatments, but compliance with recommended time of injection was better with insulin lispro.
In addition, hypoglycemia occurred in 15 people in the lispro group versus 31 people in the Regular insulin group. Five of the hypo episodes in the lispro group occurred during the nighttime period compared with 27 of the episodes in the Regular insulin group.