A new study of the much-studied Pima Indian tribe has identified a set of urine proteins that predicts who will get diabetic nephropathy ten years down the line.
The study, led by Dr. Ravi Thadhani of Massachusetts General Hospital and Harvard Medical School, looked at 62 Pima Indians with type 2 diabetes and normal kidney function. The patients were followed for ten years, and those who developed nephropathy were identified. By evaluating decade-old urine samples, the study discerned a protein profile that predicted, with 74 percent accuracy, who ended up with renal failure. Dr. Thadhani hopes that the test will eventually be able to identify future kidney failure well before microalbuminuria appears, in time to prevent its onset. Further studies are necessary to characterize the specific proteins that make up the profile, as well as more tests of their predictive power.
Sources: Diabetes Care
Diabetes In Control.com