In three comparative randomized trials, researchers at the department of medicine at Baylor College of Medicine in Houston, Texas, demonstrated that type 2s who used premixed insulins were more likely to reach blood glucose goals than those using only Lantus once daily.
“Some patients can also reach [blood glucose] goals with once-daily administration of a premixed insulin analogue,” write the researchers, who add that within trials, the incidence of both major and minor hypoglycemia with the premixed insulin analogues Humalog Mic 75/25 and NovoLog Mix 70/30 is low.
“Premixed insulin analogues can be safely used and are effective and convenient for achieving overall [blood glucose] control in patients with diabetes,” say the researchers. “In addition, given the convenience of mealtime dose administration, compliance with insulin therapy may increase with premixed insulin analogues.”
—Drugs, 2006; 66(1):31-49