Type 1 Diabetes Cured Mice

3319

A 40-day treatment of type 1 diabetes was shown to cure the disease in mice, say researchers from Massachusetts. The encouraging results could lead to finding a cure for diabetes in humans, they say.

Denise Faustman, MD, from Massachusetts General Hospital, and colleagues, published the results in the July issue of the Journal of Clinical Investigation.

The treatment entailed re-training the immune systems of the mice to stop attacking islet cells. The researchers achieved this by inducing a natural drug in the body called TNF-alpha to kill the bad cells. Then, they injected the mice with healthy donor cells that train the immune system to leave the islet cells alone instead of killing them off.

As an unexpected outcome, islet cells re-grew in the mice, providing more insulin production and stabilizing their blood sugars. Up to 75 percent of the mice maintained normal sugar levels for at least 100 days after the treatment.

“It’s really a permanent reversal of an established autoimmune disease,” said Dr. Faustman in an interview with Reuters.

Comments

comments

This post authored by
Diabetes Health Medical Disclaimer
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.