By following a low-carbohydrate diet for two weeks, obese patients were able to reduce calorie intake, lose weight and improve their diabetes.
In an inpatient comparison of two diets, 10 obese patients with type 2 diabetes were encouraged to eat food prepared by the hospital kitchen, as well as any outside food that they wanted to eat (e.g., fast food, donuts, cookies, etc.). After seven days, they were switched to a lower-carb diet consisting of 21 carbohydrate grams per day supplemented with as much protein as they wished. The participants were then instructed to adhere to this diet for 14 days.
On the low-carbohydrate diet, calorie intake decreased from 3,111 to 2,164 calories per day, resulting in a weight loss of 3.6 pounds over the course of the 14 days. Average 24-hour plasma profiles of glucose levels normalized, average A1C decreased from 7.3% to 6.8% and insulin sensitivity improved by 75 percent.
Mean plasma triglyceride and cholesterol levels also decreased.
—Annals of Internal Medicine, March 2005