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High Fructose Diet Increases Triglycerides in Healthy Lean Young Males

A study published in the December 2006 issue of The American Journal of ClinicalNutrition showed that high fructose consumption doesn’t raise insulin resistanceor ectopic lipid deposition (fat in the wrong place) in healthy lean young males, but doesheighten risk of cardiovascular disease by increasing plasma triglycerides.

This test involved 7 healthy males who were given a high fructose diet and then tested atbaseline, one week, and four weeks. The high fructose diet resulted in significant increasesin fasting plasma concentrations of triglyceride and leptin after one week, in lactate aftertwo weeks, and in glucose after four weeks.

There was no effect on body weight, body composition, blood pressure, insulin sensitivity,or muscle or liver fat. The author of the study, Dr. Luc Tappy of the University ofLausanne, Switzerland, concluded that healthy lean subjects can adapt their metabolism toincreased fructose.

He added, however, that other groups, older, fatter, or genetically more vulnerable, mightnot be so lucky. He noted that in rodents, high fructose intake does lead to both insulinresistance and ectopic lipid deposition. He and his co-workers are in the process ofstudying the effects of fructose on people with a family history of type 2 diabetes and onoverweight and middle-aged people.

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