Dyslipidemia is abnormal lipid metabolism. It is very common among people with Type 2 diabetes, and most frequently involves increased levels of triglycerides, very low density lipoprotein (VLDL) cholesterol, and low-density lipoprotein (LDL) cholesterol, as well as decreased levels of high-density lipoprotein (HDL). These abnormalities appear to be caused by increased secretion of VLDL particles from the liver due to increased concentrations of free fatty acids and glucose.
Treatment of dyslipidemia is recommended for individuals with Type 2 diabetes who exhibit any of the following:
- LDL cholesterol levels of 130 mg/dl and above
- triglyceride levels of 200 mg/dl and above
- HDL cholesterol levels of 35 mg/dl and below (non-HDL levels of 160 mg/dl and above)
(Pharmacotherapy, July-August, 1993).