Many heart attacks are caused by platelets sticking together and forming clots that block blood flow. Aspirin reduces clotting by inhibiting an enzyme that helps platelets stick together. But if you have diabetes and are taking low-dose aspirin to prevent platelets from gumming up your blood vessels, your low dose might be a little too low.
According to a study presented by Dr. Paul Gurbel at the 56th annual session of the American College of Cardiology, diabetic people may be resistant to the effect of aspirin at the usual low dose.The study examined 120 people with stable coronary artery disease, thirty of whom had diabetes. Increasing the daily dose of aspirin from the standard 81 milligrams to 325 milligrams reduced collagen-induced platelet aggregation among diabetic patients from 54 percent to 29 percent, the level seen in people without diabetes. Larger-scale studies are needed, said Dr. Gurbel, to test the effectiveness of higher aspirin doses in diabetic patients and the impact of diabetes on the responsiveness of platelets to aspirin.
Sources: Doctor’s Guide