Red Wine Wonder Compound May Also Improve Kidney Function

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By: Daniel Trecroci

Indian researchers believe that the compoundresveratrol, found in the skins of red grapes, is the reason certain red wines may be good forheart health. Now, it appears to benefit kidneysas well.

“Resveratrol—a polyphenolic phytoalexin present in red wine—is known to possess potent antioxidant properties, and thus we aimed to examine its effect on [kidney] function and oxidative stress in [diabetic rats],” write researchers from the University Institute of Pharmaceutical Sciences at Panjab University in Chandigarh, India.

Diabetes was induced in rats through aninjection of streptozotocin. The rats were thendivided into three groups: controls, diabeticrats and diabetic rats treated with 5 and 10milligrams of resveratrol.

After six weeks, the diabetic rats exhibited kidney dysfunction, as evidenced by reduced creatinine and urea clearance, and proteinuria along with a marked increase in oxidative stress. Treatment with resveratrol improved the kidney dysfunction and oxidative stress in the diabetic rats.

“The present study reinforces the important role of oxidative stress in diabetic kidney and points toward the possible antioxidative mechanism being responsible for the renoprotective action of resveratrol,” say the researchers.

Pharmacology, November 2005

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