New Therapy Helps Freshly Isolated Islets Survive


By: J. Chanslor

Researchers in Italy and the United States collaborated to determine whether the peptide hormone glucagon-like peptide 1 (GLP-1) could improve function and inhibit programmed cell death or suicide.

Human islets were cultured for five days either with or without GLP-1. They were studied for viability, the absence or presence of cell suicide and glucose-dependent insulin production.

Results showed better-preserved three-dimensional islet morphology in the GLP-1 group than the controls. Reduction of suicide cells was particularly evident at day three.

Researchers concluded that GLP-1 preserves morphology, improves functions and inhibits cell suicide.

-Endocrinology, December 2003



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