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Powerful Imaging Technology Helps to Uncover Important Interaction Involved in Tolerance
This press release is an announcement submitted by UCSF Diabetes Center, and was not written by Diabetes Health.
Using laser-scanning microscopy to understand immune cell actions in diabetes.
The body's immune system is supposed to "tolerate" itself and distinguish "self" from "non-self." Autoimmune diseases such as type 1 diabetes result from the breakdown of this system, causing immune cells to attack and destroy insulin-producing beta cells or "self." In the November issue of Nature Immunology, Brian Fife, PhD and collaborators including senior author Jeffrey Bluestone, PhD share how they have uncovered a basic process that helps control immune cell activation and tolerance.
By utilizing two-photon laser-scanner microscopy to look at individual immune cells in a mouse model of type 1 diabetes, they discovered that when a molecule found on the immune cell called Programmed death 1 (PD-1) binds to another molecule found on another cell, PD-L1, the cells are prevented from forming stable interactions and have increased movement. These fast-moving cells interact less with the cells in the pancreas, thereby preventing type 1 diabetes.
The team hopes that this research will help in the development of a new generation of tolerogenic drugs that will "turn off" selected parts of the immune system, leaving the disease-fighting capabilities intact. A UCSF postdoctoral fellow for six years, Dr. Fife is now a faculty member with the University of Minnesota's Center for Immunology.
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UCSF Diabetes Center e-Update
Categories: Diabetes, Insulin, Research, Type 1 Issues
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Nov 17, 2009
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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