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Diabetes and Adoption
Rachel and her husband chose to adopt a baby instead of meeting the challenges of handling a high risk pregnancy and Rachel’s type 1 diabetes at the same time. She shares their thought process and ultimate happy ending about the decision to bring a child into their lives.
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Chris Matthews Makes Time for Diabetes
Hosting Hardball on MSNBC and The Chris Matthews Show keep Chris Matthews working long hours. But Matthews got a lesson in priorities and made some life changes when he was diagnosed with type 2.
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A Chihuahua with Diabetes
Olivia and her dog both have diabetes and today they comfort and encourage each other through the rigors of dealing with the disease. Plus, find out what it means when your domestic pet is diagnosed with diabetes.
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Smoking and Diabetes
Smoking has severe effects on your diabetes and your health. Learn why diabetes and smoking are an especially bad combination and get some tips from the experts on how to quit.
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Continuous Glucose Monitors
CGM is a relatively new technology, but the information it provides is invaluable. Find out what CGM offers and whether it could help you.
The must-have resource for physicians, educators and medical professionals who focus on the treatment of diabetes.
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Each bi-monthly issue of Diabetes Health Professional is a self-contained handbook covering products, educational resources and the latest diabetes research, complimented by balanced editorial focused on medical news, drug prescription information, clinical practice recommendations and changing treatment options.
Each quarter we send you the latest, most updated research guides, product guides and educational resource guides available for you and your patients.
Each week the Diabetes Health E-Newsletter delivers links to the very latest in news, reviews, blogs and videos from Diabetes Health direct to your inbox.
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Latest Type 1 Issues Articles
As a result, the beta cells regenerated and were able to begin producing insulin - essentially reversing the diabetes.
They've Done it in Mice... Now They Plan to Cure Type 1 in Humans
Researchers at Children’s Hospital in Pittsburgh have started an FDA-approved phase 1 test in humans of a lab procedure that successfully reversed type 1 diabetes in mice.
In the original procedure, scientists extracted dendritic cells from the blood of a diabetic mouse. Dendritic cells are immune cells that identify foreign substances and spur infection-fighting T cells to defend the body. Recent research has shown that in mice with diabetes, dendritic cells mistake islet cells in the pancreas for foreign invaders, then wrongly incite attacks upon them—proof of the autoimmune nature of type 1 diabetes.
The scientists “enhanced” the extracted cells with “blockers” that inhibit T cell response, then injected the treated cells back into the mouse. Over several weeks, the beefed-up dendritic cells were able to completely shut off the T cell attacks on the pancreatic beta cells. As a result, the beta cells regenerated and were able to begin producing insulin—essentially reversing the diabetes.
Insulin Will Assist Dendritic Cell “Targeting”
The phase 1 trial, which began in March, involves 15 type 1 patients over 18 years of age. The trial team is led by Dr. Massimo Trucco, the Hillman Professor of Pediatric Immunology at Children’s Hospital and a professor of Pediatrics at the University of Pittsburgh School of Medicine.
Dr. Trucco and his team want to combine the dendritic cells with small portions of insulin, in the hope that the insulin will guide the dendritic cells directly to the T cells. Adding the insulin will ensure that the dendritic cells specifically block T cell destruction of the beta cells and do not otherwise interrupt the immune system.
Categories: Other Lab Tests, Type 1 Issues
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