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Diabetes Health
Diabetes Health Professional
- Taken for Health or Taken for a Ride?
Are vitamins and supplements really necessary for people with diabetes? John White discusses the nature and eff ects of the most common ones people take in addition to their medications.
- Cinnamon: Should It Be Taken as a Medication?
The verdict is in, says John White: Despite some intriguing initial results, subsequent studies have pretty much laid to rest cinnamon’s reputation as a pseudo-insulin.
- Sweeter (and Better) Than Sugar?
There are so many non-sugar sweeteners out there – where to begin? Well, begin here as the famous medical duo of Drs. Michael and Mary Dan Eades explore the pros and cons of various artifi cial sweeteners.
- Belly Busters for Beginners
Out of shape? Want to get better? Well, working your abdominals to get them into fi ghting trim is the classic way to start an exercise program. Ann Swank tells you how.
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Latest Type 2 Issues Articles
Januvia Okayed for Use With Sulfonylureas
20 November 2007
Januvia, also known as sitagliptin phosphate, is a DPP-IV inhibitor. It prevents, or inhibits, DPP-IV from inactivating GLP-1. GLP-1 is a naturally produced hormone that increases insulin secretion in response to food.
Unfortunately, it disappears rapidly from the body because DPP-IV breaks it down. We want to keep it around, and that's why a DPP-IV inhibitor like Januvia is helpful in controlling diabetes. (See "The Incretin Saga: Mimetics, Enhancers, and Inhibitors" for a primer on how this all works.)
Januvia was approved last year for use by itself and for adding to metformin or the thiazolidinediones (Actos and Avandia) if those weren't enough to do the job alone. Now the FDA has also approved Januvia as an initial therapy with metformin and as an add-on to sulfonylureas or to a combination of both a sulfonylurea and metformin when those two drugs aren't providing adequate control.
Januvia's manufacturer, Merck, also updated the drug's Warning and Precautions label to advise patients to stop taking Januvia if they develop an allergic reaction. The bolstered warning was based upon reports of rare hypersensitivity reactions in patients taking Januvia, including anaphylaxis, angioedema, and Stevens-Johnson syndrome. The FDA indicated, however, that it was not overly concerned by the reports.
Source: Reuters; FDA, October 2007
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upon taking januvia, viagra, cialis and levitra become ineffective. i can find nothing in information about this effect, but
it happened to me. immediately after stopping
januvia, viagra became effective again.
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