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Diabetes Health
Diabetes Health Professional
- Taken for Health or Taken for a Ride?
Are vitamins and supplements really necessary for people with diabetes? John White discusses the nature and eff ects of the most common ones people take in addition to their medications.
- Cinnamon: Should It Be Taken as a Medication?
The verdict is in, says John White: Despite some intriguing initial results, subsequent studies have pretty much laid to rest cinnamon’s reputation as a pseudo-insulin.
- Sweeter (and Better) Than Sugar?
There are so many non-sugar sweeteners out there – where to begin? Well, begin here as the famous medical duo of Drs. Michael and Mary Dan Eades explore the pros and cons of various artifi cial sweeteners.
- Belly Busters for Beginners
Out of shape? Want to get better? Well, working your abdominals to get them into fi ghting trim is the classic way to start an exercise program. Ann Swank tells you how.
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Latest Type 2 Medications Articles
Sitagliptin and Metformin a Useful Combo For Type 2s
12 November 2007
A recent study has found that the combination of metformin and sitagliptin lowers A1c's better than either drug alone, apparently because their different mechanisms work together synergistically.
Sitagliptin (Januvia) is a DPP-4 inhibitor; that is, it helps prevent DPP-4 from inactivating GLP-1, a gut hormone that regulates blood glucose. (For a lesson on how that works, see "The Incretin Saga: Mimetics, Enhancers, and Inhibitors".) Metformin (Glucophage) is an older drug that reduces the amount of glucose synthesized by the liver, decreases the absorption of glucose from the gastrointestinal tract, and increases insulin sensitivity.
The study examined 1,091 people with type 2 diabetes who were divided into four groups: sitagliptin plus metformin, sitagliptin alone, metformin alone, or a placebo. Their average starting A1c was 8.8%. After the 24-week study, 66 percent of the combo group had an A1c of less than 7%, and 44 percent of them had dropped to 6.5%.
The single drug groups also experienced improvement, but significantly less than the combo group. The incidence of hypoglycemia in the combo group was about the same as that of the placebo group.
Sources: Medline Plus; Diabetes Care, August 2007
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