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Diabetes Health Professional

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  • Diabetes and Adoption

    Rachel and her husband chose to adopt a baby instead of meeting the challenges of handling a high risk pregnancy and Rachel’s type 1 diabetes at the same time. She shares their thought process and ultimate happy ending about the decision to bring a child into their lives.

  • Chris Matthews Makes Time for Diabetes

    Hosting Hardball on MSNBC and The Chris Matthews Show keep Chris Matthews working long hours. But Matthews got a lesson in priorities and made some life changes when he was diagnosed with type 2.

  • A Chihuahua with Diabetes

    Olivia and her dog both have diabetes and today they comfort and encourage each other through the rigors of dealing with the disease. Plus, find out what it means when your domestic pet is diagnosed with diabetes.

  • Smoking and Diabetes

    Smoking has severe effects on your diabetes and your health. Learn why diabetes and smoking are an especially bad combination and get some tips from the experts on how to quit.

  • Continuous Glucose Monitors

    CGM is a relatively new technology, but the information it provides is invaluable. Find out what CGM offers and whether it could help you.

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An Oxygen Sandwich Helps Pancreatic Stem Cells Become Beta Cells

Linda von Wartburg
Sep 27, 2007

Despite their best efforts, researchers have been having a hard time getting pancreatic stem cells to grow up into beta cells that can be used for transplantation.

Apparently, part of the problem has been that the stem cells, sitting in their suffocating little Petri dishes, haven't been getting the oxygen bath that they need to develop into beta cells.

So researchers from the Diabetes Research Institute, at the University of Miami, created a way to sandwich the stem cells between two oxygen sources: a top one that diffuses air through the culture medium, and a bottom one that diffuses air through a silicon membrane mixed with perfluorocarbon, a rich oxygen reservoir.

Hitting the stem cells from both sides with oxygen proved very effective, at least with mouse pancreatic stem cells: They morphed into beta cells at a great rate, producing thirty times as much insulin as the cultures raised without the nourishing sandwich.

Because the sandwich more closely mimics the physiological conditions under which stem cells mature in the body, the researchers believe it will be of use to scientists no matter what kind of stem cells they're trying to raise up.

Source: Diabetes Research Institute Foundation


Categories: Islet & Pancreas Transplant, Professional Issues


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