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Diabetes Health Professional

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  • Diabetes and Adoption

    Rachel and her husband chose to adopt a baby instead of meeting the challenges of handling a high risk pregnancy and Rachel’s type 1 diabetes at the same time. She shares their thought process and ultimate happy ending about the decision to bring a child into their lives.

  • Chris Matthews Makes Time for Diabetes

    Hosting Hardball on MSNBC and The Chris Matthews Show keep Chris Matthews working long hours. But Matthews got a lesson in priorities and made some life changes when he was diagnosed with type 2.

  • A Chihuahua with Diabetes

    Olivia and her dog both have diabetes and today they comfort and encourage each other through the rigors of dealing with the disease. Plus, find out what it means when your domestic pet is diagnosed with diabetes.

  • Smoking and Diabetes

    Smoking has severe effects on your diabetes and your health. Learn why diabetes and smoking are an especially bad combination and get some tips from the experts on how to quit.

  • Continuous Glucose Monitors

    CGM is a relatively new technology, but the information it provides is invaluable. Find out what CGM offers and whether it could help you.

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More Evidence Linking Insulin Resistance to Alzheimer's Disease

Linda von Wartburg
Jul 28, 2007

Diabetes and pre-diabetes are associated with a seventy-five percent increased risk of Alzheimer's disease. Research has already shown that insulin resistance, with its accompanying high levels of circulating insulin, increases brain and spinal cord inflammation markers and neurotoxic peptides (molecules that cause brain and nervous system damage), just like early Alzheimer's.

Now there's more evidence linking insulin resistance to Alzheimer's. According to research by Dr. Suzanne Craft of the University of Washington School of Medicine, brain scans of insulin-resistant adults reveal reduced glucose metabolism in certain brain regions; the pattern is identical to that seen in people who get Alzheimer's years down the road.

The findings imply that reducing insulin resistance should improve memory and reduce the risk of future Alzheimer's. In a study to test that theory, Dr. Craft gave 24 insulin-resistant subjects an insulin sensitizer (which lowers insulin resistance); she gave 23 an insulin secretagogue (which causes more insulin to be secreted by the beta cells), and 24 more a placebo.

Four months later, the subjects who showed improvements in insulin sensitivity also experienced improved memory; if insulin resistance did not improve, then neither did memory.

Source: 67th Scientific Sessions of the ADA


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