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More on Ultralente Insulin
A report published in the August 1992 issue of Diabetes Care predicts that the early morning high blood sugars (hyperglycemia) experienced by Type I diabetes patients could possibly be the result of their current insulin therapy. With a twice-daily dosage of combined human lente and regular insulin (HL/R) injections, blood sugar levels may rise from a lack of insulin early in the morning, when it is needed most.
Researchers from the Department of Pediatrics and Medicine at the Indiana University Medical Center, Indianapolis, compared the effects of human ultralente insulin (HUL) and human lente insulin on morning fasting blood glucose levels. The purpose of the study was to determine whether a twice-daily regimen of human ultralente insulin combined with regular insulin (HUL/R) would improve raised morning blood sugar levels and metabolic control in children with Type I diabetes.
The researchers developed a twice-daily injection regimen using HUL insulin in their study. The authors of the report note that since HUL insulin has a longer duration and a diminished peak, it would increase the amount of insulin available in the early morning hours.
Thirty-one children with Type I diabetes were selected to carry out the study. After continuing the patients on four more weeks of HL/R injections, the researchers split the group into HUL/R insulin users and HL/R insulin users. The trial lasted for twelve weeks, with each patient taking an injection once before breakfast and once before the evening meal.
After the twelve week trial, the researchers concluded that young Type I diabetes patients using twice-daily doses of human ultralente (HUL) insulin combined with regular insulin can safely improve fasting blood glucose levels and lower the magnitude of the morning glucose rise. HUL/R did not improve metabolic control.
Categories: Blood Glucose, Blood Sugar, Diabetes, Insulin, Research, Type 1 Issues
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Nov 1, 1992
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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