Naturally Occurring Hormone Suppresses Appetite

3779

Identifying foods that cause the release of a naturally occurring gut hormone known as PYY3-36—or creating a pill that contains the hormone—may help in obesity control, say researchers who studied the effects of PYY3-36 in both rodents and human volunteers.

In a randomized, double-blind, crossover trial, 12 human subjects were infused with either PYY3-36 or saline for 90 minutes. They were then offered an unlimited buffet meal two hours later.

Those who received infusions of the hormone ate 36 percent fewer calories, and perceived hunger levels declined by up to 40 percent over the next 12 hours.

“Rather than using extreme diet measures such as dieting pills, or even surgery, PYY3-36 should be able to provide a far safer and effective alternative,” says lead author Rachel Batterham from the Imperial College of London at the Hammersmith Hospital.

PYY3-36 suppresses appetite by acting as a neurotransmitter on the hypothalamus area of the brain.

Nature, August 8, 2002

Comments

comments

This post authored by
Diabetes Health Medical Disclaimer
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.