GSK-3: The Less the Better

5510

By: Linda von Wartburg

Scientists have been having fun again making themselves specially engineered mice. This time they knocked the gene that makes glycogen synthase kinase-3 (GSK-3) right out of their ever-accommodating mice.

Without the gene, the mice couldn’t make the GSK-3 enzyme. And without that enzyme, they were more insulin-sensitive than their unengineered brethren. Because the mice were better able to use insulin to regulate their blood sugar levels, they could store more sugar in their livers.

The researchers believe that someday, chemical inhibitors of GSK-3 may prove useful to increase the effectiveness of insulin in humans.

Sources: EurekAlert; Cell Metabolism, October 2007

Comments

comments

Diabetes Health Medical Disclaimer
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.