Glucose Triggers the Development of Embryonic Beta Cells

5234

A new study out of London and Paris indicates in the developing embryo, beta cells form in the pancreas in response to the presence of glucose. Glucose triggers a gene called Neurogenin3 to switch on another gene, neuroD, which is critical for the normal development of beta cells. If glucose levels are low, the gene doesn’t switch on and the beta cells don’t develop.

The researchers discovered this action of glucose by examining tissues cultured from the pancreases of very young rat embryos. By showing that glucose regulates the formation of beta cells, they are a step closer to figuring out how to create beta cells from stem cells. It’s also possible that their findings may lead to the development of drugs to enhance the action of glucose in encouraging the growth of healthy beta cells.

* * *

Source: Journal of Biological Chemistry

Click here to view/write comments
Diabetes Health Medical Disclaimer
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.