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Canadian scientists have found that nobiletin, a substance found in high concentrations in tangerines, thwarted obesity and the onset of diabetes in lab mice. The researchers at the University of Western Ontario fed the mice a high-sugar, high-fat diet that mimicked the diet of many people in Western societies. One group of animals became obese, developing fatty livers and elevated levels of cholesterol and insulin-typical precursors to type 2 diabetes and cardiovascular disease. But a second group of mice, given the flavonoid nobiletin, did not develop the symptoms of the first group. The nobiletin prevented fatty buildup in the liver by blocking the genes that control the production of fat.
4 comments - Apr 30, 2011 -
Italian and Greek researchers conducting a meta-analysis* of the diets of more than 500,000 people have concluded that the Mediterranean diet reduces the risk of metabolic syndrome, a cluster of risk factors that are common precursors to type 2 diabetes. Those factors include overweight or obesity, a sedentary lifestyle, high blood sugar, high triglyceride levels, high blood pressure, and high "bad" cholesterol.
The Mediterranean diet is high in fruit, vegetables, whole grain foods, and low-fat dairy products. Proteins include fish, legumes, poultry, tree nuts, and mono-unsaturated fatty acids from olive oil. Alcohol intake is moderate and almost always in conjunction with meals. Red meat is only an occasional menu item.
The scientists looked at 50 studies that involved more than 500,000 people, then extrapolated the effects of a Mediterranean diet from them. Although the meta-analysis pointed to the usefulness of the Mediterranean diet in fending off metabolic syndrome, its authors said that their conclusion is tentative, given the need for more research on the topic.
The study was published in the March 15 issue of the Journal of the American College of Cardiology.
* A meta-analysis looks at a number of similar studies and tries to derive new and useful results from them by detecting common patterns among them.
0 comments - Apr 12, 2011 -
While smoking is commonly associated with a higher risk of developing a serious disease, it's not often that second-hand smoke or being an ex-smoker is considered even riskier. If the disease is type 2 diabetes, however, it is.
0 comments - Apr 5, 2011 -
Michael Hamman is a 63-year-old contractor. He recalls, "I first was diagnosed with type 2 diabetes five or six years ago. I probably had elevated blood sugar well in advance of that, but I was unaware of it. I don't remember how high my blood sugar was at the time, but I think my A1C was 7.5%. My blood sugar's never really been awful. Since I started monitoring myself, my sugar readings are normally between 150 and 165. I think it was pushing 200 before I was medicated, but the medications brought it down. They started me on glyburide and I took that for a long time, and then the A1C was moving up again, so they added the metformin. The A1C now is down in the mid-sixes. They consider it controlled, not well controlled or as good as it could be, but certainly for someone my size, it's probably as good as you can get."
1 comment - Mar 25, 2011 -
The U.S. Food and Drug Administration has accepted an application to review dapagliflozin, a drug for the treatment of type 2 diabetes that is being developed by Bristol-Myers Squibb and AstraZeneca.
0 comments - Mar 22, 2011 -
Evolution works in strange ways. What serves as an advantage at one point in time can sometimes prove a problem later, when the world has changed. It looks like that might be the case with type 2 diabetes, according to researchers from San Diego, California.
2 comments - Mar 21, 2011 -
Researchers at the Children's Hospital in Boston, led by Umut Ozcan, MD, have found a regulatory protein that lowers blood sugar when it is high due to either lack of insulin or a decreased sensitivity to insulin.
0 comments - Feb 24, 2011 -
Taking 10,000 steps a day, or walking about five miles, is very, very good for you. It's even better than walking 3,000 steps a day, which is also extremely beneficial if you walk briskly enough to do it in 30 minutes. The 10,000 steps philosophy is not new--there's even a weight-loss book or two on the topic. But now the 10,000 step regimen has also been linked to an increase in insulin sensitivity in middle-aged adults.
1 comment - Jan 20, 2011 -
Keeping the lights on all night might keep away the monsters under the bed, but it also keeps away the "hormone of darkness," melatonin, according to a new study in the Journal of Clinical Endocrinology and Metabolism. Melatonin, which is secreted into the blood by the brain's pineal gland at night, is involved in the circadian rhythm. Scientists believe that disrupting circadian rhythms can contribute to metabolic disease. Specifically, melatonin receptor genes have been linked to type 2 diabetes. Melatonin is also a powerful antioxidant that may help prevent cancer.
3 comments - Jan 19, 2011 -
With nearly 16 million Americans living today with pre-diabetes, a condition that is the precursor to type 2 diabetes, and half of all Americans expected to have some form of diabetes by the year 2020, healthy eating is more important than ever (1,2). But here is some good news: a recent scientific study shows that incorporating almonds into your diet can help treat and possibly prevent type 2 diabetes, as well as cardiovascular disease.
0 comments - Dec 15, 2010 -
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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